Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome
نویسندگان
چکیده
منابع مشابه
Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome.
BACKGROUND The sperm chromatin structure assay (SCSA) has been suggested as a predictor of fertility in vivo as well as in vitro. The available data however, have been based on limited numbers of treatments. We aimed to define the clinical role of SCSA in assisted reproduction. METHODS A total of 998 cycles [387 intrauterine insemination (IUI), 388 IVF and 223 ICSI] from 637 couples were incl...
متن کاملClinical significance of sperm DNA damage in assisted reproduction outcome.
BACKGROUND Sperm DNA damage shows great promise as a biomarker of infertility. The study aim is to determine the usefulness of DNA fragmentation (DF), including modified bases (MB), to predict assisted reproduction treatment (ART) outcomes. METHODS DF in 360 couples (230 IVF and 130 ICSI) was measured by the alkaline Comet assay in semen and in sperm following density gradient centrifugation ...
متن کاملImplication of sperm processing during assisted reproduction on sperm DNA integrity
tau.amegroups.com © Translational Andrology and Urology. All rights reserved. The authors (Drs. Borini, Tarozzi and Nadalini), in their invited commentary (1) in response to the practice recommendations by Agarwal et al. (2), raised several valid arguments about sperm DNA fragmentation (SDF) testing. In our response to Borini et al., we intend to share additional information on SDF for the read...
متن کاملIs sperm DNA integrity assessment useful?
YES of the dye or enzyme to the sites of damaged DNA) 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 TESTS of sperm DNA integrity have been used increasingly in the evaluation of the infertile man. These tests have been developed to further our understanding of spermatogenesis and sperm function, and to...
متن کاملDiagnostic value of sperm DNA fragmentation and sperm high-magnification for predicting outcome of assisted reproduction treatment.
Over the last years, major improvements in the field of male infertility diagnosis have been achieved. The aim of this study was to determine the diagnostic usefulness of sperm DNA integrity and sperm vacuolisation for predicting outcome in infertile couples undergoing in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) treatments. A cohort study from 152 infertile couples ...
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ژورنال
عنوان ژورنال: Yearbook of Urology
سال: 2008
ISSN: 0084-4071
DOI: 10.1016/s0084-4071(08)79063-8